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New BioDiscovery strikes deal with Rhone-Poulenc
November 26, 1998

BioDiscovery announces that it has signed an agreement to commercialise products from its joint venture with CSIRO Entomology.

"This is the first pay-off from a far-sighted joint venture between CSIRO Entomology and BioDiscovery Limited to systematically screen Australian insects for agrochemical and pharmaceutical leads", said Australia's Industry Minister, Nick Minchin.

Australian insect extracts produced by CSIRO are an exciting new source of natural products for screening by pharmaceutical and agrochemical companies in their ongoing endeavour to identify "hit" compounds which may lead to novel chemicals and drugs.

Rhône-Poulenc is a leading life sciences company, growing through innovations in human, plant and animal health. The company employs 68,000 people in 160 countries worldwide, and sales in 1997 amounted to some US$15 billion. Rhône-Poulenc Agro, the crop protection division, has
established new methodologies in the search for novel chemistries to support its growth.

A number of valuable crop protection products have been developed as a result of identifying pesticidal activity in natural organisms, plants, fungi and invertebrates. Rhône-Poulenc Agro recognises that the extracts isolated from Australian insects in the BioDiscovery Joint Venture have potential to lead to compounds which are active in crop protection.

Under the licence agreement Rhône-Poulenc Agro will access extracts from the CSIRO-BioDiscovery insect library over a three-year period. BioDiscovery will receive an up-front payment of AUD$500,000 plus two further payments of AUD$500,000 on the first and second anniversaries of the agreement, a total of AUD$1,500,000 in fixed payments. Additional payments will be made in the events of a compound showing activity and a compound undergoing small-scale trials. Rhône-Poulenc Agro estimates that these additional payments could be in
excess of AUD$1,000,000. Finally, Rhône-Poulenc Agro will pay BioDiscovery royalties should any compounds lead to the sale of agrochemical products.

Agrochemicals are only one application of the insect library developed in BioDiscovery's collaboration with CSIRO Division of Entomology. "Natural products form the basis of many of the top-selling drugs, and BioDiscovery is actively seeking licensing arrangements with pharmaceutical drug development companies to further enable the exploitation of the insect library", says BioDiscovery's CEO, Professor Joan Dawes.

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