Senesco Technologies reports third quarter fiscal 2003 financial results

New Brunswick, New Jersey
May 16, 2003

Senesco Technologies, Inc. ("Senesco" or the "Company") (AMEX:SNT) reported financial results for the three months ended March 31, 2003.

The net loss for the third quarter of fiscal 2003 was $515,683, or $0.04 per share, compared with a net loss of $482,820, or $0.05 per share, for the comparable period in fiscal 2002. For the third quarter of fiscal 2003, the Company reported no revenue, similar to its comparable period in fiscal 2002.

Total operating expenses for the third quarter of fiscal 2003 were $532,090, compared with $495,495 for the comparable period in fiscal 2002. The increase of $36,595, or 7.4%, was attributable primarily to an increase in research and development expenses, which were partially offset by a decrease in general and administrative expenses and stock-based compensation.

Research and development expenses rose substantially to $237,687, from $100,949 in the comparable period in fiscal 2002. The increase of $136,738, or 135.5%, was attributable primarily to the expansion of the Company's research and development program at the University of Waterloo, the implementation of the Company's mammalian cell research programs and the implementation of new plant research being conducted in connection with a collaboration agreement with Anawah, Inc. (formerly Tilligen, Inc.).

General and administrative expenses for the third quarter of fiscal 2003 were $294,403, down slightly from $300,400 for the comparable period in fiscal 2002. The decrease of $5,997, or 2.0%, was attributable primarily to lower payroll and professional fees, which were mostly offset by an increase in investor relations costs and depreciation and amortization.

The Company reported no stock-based compensation for the third quarter of fiscal 2003, compared with $94,146 for the comparable period in fiscal 2002. The decrease of $94,146, or 100%, was primarily the result of a decrease in stock options granted and becoming vested to members of the Scientific Advisory Board and consultants and warrants granted and becoming vested to certain financial advisors.

At March 31, 2003, Senesco had cash and investments of $3.1 million and working capital of $2.8 million.

"Our recent fiscal quarter was marked by the receipt of our first patent, reinforcing our commitment to protect our intellectual property," stated Bruce Galton, President and Chief Executive Officer of Senesco. Mr. Galton added: "We are actively continuing our discussions with the Tianjin Academy of Agricultural Sciences regarding its letter of intent for the exclusive use of the Company's technology in a variety of fruit and vegetable crops in China (the "LOI") and have initiated contact with a Chinese biotechnology seed company. This is a necessary step in order to secure the financing envisioned and to commercialize the seeds to be developed pursuant to the LOI. However, due to the current SARS health crisis in China, certain parties within various governmental positions in China have been difficult to contact, which has made the process more lengthy than we originally anticipated. We expect discussions to be ongoing over the next several months."

Recent Corporate Highlights

In March, Senesco announced that it was awarded Patent No. 6,538,182 from the U.S. Patent and Trademark Office entitled "DNA Encoding a Plant Deoxyhypusine Synthase, A Plant Eukaryotic Initiation Factor 5A, Transgenic Plants and a Method for Controlling Senescence Programmed Cell Death in Plants."

Also in March, the Company announced that inhibiting the expression of its patent-pending gene, apoptosis eucaryotic Initiation Factor 5A ("Factor 5A"), has been shown to reduce apoptosis (cell death) in preclinical studies with human lamina cribrosa cells from the optic nerve head of human eyes. The lamina cribrosa is a supporting structure for the optic nerve at the point of connection with the eye. Apoptosis is a critical factor leading to blindness in glaucoma patients.

Also during March, the Company announced results from certain preclinical studies being conducted at the University of Colorado School of Medicine in Denver. The Company's patent-pending gene, Factor 5A, has been correlated in ischemic heart tissue to two cytokines, interleukin-1 beta and interleukin-18 ("IL-1" and "IL-18"). IL-1 is associated with a variety of inflammatory diseases and IL-18 has been reported to cause premature programmed cell death.

Senesco takes its name from the scientific term for the aging of plant cells: "senescence." The Company has developed technology that regulates the onset of cell death. Delaying cell breakdown in plants extends freshness after harvesting, while increasing crop yields, plant size and resistance to environmental stress for flowers, fruits and vegetables. The Company believes that its technology can be used to develop superior strains of crops without any modification other than delaying natural plant senescence. Senesco has begun to explore ways to trigger or delay cell death in mammals (apoptosis) to determine if the technology is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain diseases such as Alzheimer's, glaucoma, ischemia and arthritis, among others. Senesco partners with leading-edge companies and earns research and development fees for applying its gene-regulating platform technology to enhance its partners' products. Senesco is headquartered in New Brunswick, New Jersey, and utilizes research laboratories at the University of Waterloo in Ontario, Canada, and the University of Colorado in Denver, Colorado.

 

               SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY
                     (A DEVELOPMENT STAGE COMPANY)
            CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                              (unaudited)

                                   For the               For the
                                 Three Months          Three Months
                                Ended March 31,       Ended March 31,
                                     2003                  2002

Revenue                                 $--                   $--

Operating Expenses:
 General and administrative         294,403               300,400
 Research and development           237,687               100,949
 Stock-based compensation                --                94,146
Total Operating Expenses            532,090               495,495

Loss From Operations               (532,090)             (495,495)

Sale of state income tax loss            --                    --
Interest income, net                 16,407                12,675
Net Loss                          $(515,683)            $(482,820)

Basic and Diluted Net Loss Per
 Common Share                        $(0.04)               $(0.05)

Basic and Diluted Weighted
 Average Number of Common
 Shares Outstanding              11,880,045            10,527,346


                                 For the      For the      From
                                 Nine         Nine         Inception
                                 Months       Months       on July 1,
                                 Ended        Ended        1998,
                                 March 31,    March 31,    through
                                 2003         2002         March 31,
                                                           2003

Revenue                             $10,000     $125,000     $210,000

Operating Expenses:
 General and administrative       1,056,416      976,528    6,084,193
 Research and development           597,774      257,925    2,097,350
 Stock-based compensation           137,177      635,186    1,498,435
Total Operating Expenses          1,791,367    1,869,639    9,679,978

Loss From Operations             (1,781,367)  (1,744,639)  (9,469,978)

Sale of state income tax loss       130,952      150,551      341,834
Interest income, net                 57,690        5,227      105,098
Net Loss                        $(1,592,725) $(1,588,861) $(9,023,046)

Basic and Diluted Net Loss Per
 Common Share                        $(0.13)      $(0.18)

Basic and Diluted Weighted
 Average Number of Common
 Shares Outstanding              11,880,045    8,925,427


              SENESCO TECHNOLOGIES, INC. AND SUBSIDIARY
                    (A DEVELOPMENT STAGE COMPANY)
                 CONDENSED CONSOLIDATED BALANCE SHEET

                                                March 31,   June 30,
                                                  2003        2002
                                               (unaudited)
                    ASSETS

CURRENT ASSETS:
Cash and cash equivalents                         $76,239    $798,711
Short-term investments                          3,045,108   2,872,432
Accounts receivable                                    --      75,000
Prepaid expenses and other current assets         170,917      55,772
   Total Current Assets                         3,292,264   3,801,915

Long-term investments                                  --     993,535
Property and equipment, net                        82,867      79,581
Intangibles                                       465,614     347,978
Security deposit                                    7,187       7,187
   TOTAL ASSETS                                $3,847,932  $5,230,196

     LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
Accounts payable                                  $62,131     $80,201
Accrued expenses                                  365,524     296,347
       Total Current Liabilities                  427,655     376,548

Grant payable                                      90,150      67,972
   TOTAL LIABILITIES                              517,805     444,520

STOCKHOLDERS' EQUITY:

Preferred stock, $0.01 par value; authorized
 5,000,000 shares, no shares issued                    --          --
Common stock, $0.01 par value; authorized
 30,000,000 shares, issued and outstanding
 11,880,045 shares                                118,800     118,800
Capital in excess of par                       12,234,373  12,157,679
Deficit accumulated during the development
 stage                                         (9,023,046) (7,430,321)
Deferred compensation related to issuance of
 options and warrants                                  --     (60,482)
 Total Stockholders' Equity                     3,330,127   4,785,676

 TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY    $3,847,932  $5,230,196
News release
5845

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