Australia
October 24, 2005
The patent landscape for RNAi
'gene silencing' – including CSIRO's
hairpin RNAi technology – has been significantly clarified
following the resolution of several opposition and
re-examination cases in Australia.
RNAi-based
gene silencing has been hailed as one of the most significant
advances in biological and medical science in recent years.
Hairpin RNAi
is used widely as a research tool to identify the function of
genes in plants and animals and has huge scope for developing
novel traits for use in agriculture, veterinary and medical
science.
CSIRO has
now been granted a patent for hairpin RNAi in Australia (No.
760041) after the completion of both an opposition process and a
re-examination by the Australian Patent Office. This follows the
granting of similar patents to CSIRO in China and New Zealand.
“Our patent
application lodged in 1998 and based on CSIRO's early
development of hairpin RNAi has been substantiated through this
testing process. The granted patent covers use of the technology
in plants, animals and humans,” says Dr Rob de Feyter,
Intellectual Property Manager at CSIRO Plant Industry.
In a second
case in Australia, CSIRO was successful in opposing a patent
application (No. 747872) in the name of Syngenta Ltd, with broad
claims to RNAi gene silencing. The opposition was recently
resolved by withdrawal of Syngenta's application.
In a third
case, two patents (Nos. 743316, 2001100608) co-owned by CSIRO
and Benitec Australia Ltd,
were maintained after re-examination.
These
patents claim use of DNA-delivered RNAi in animal and human
cells. Benitec has commercial rights for use in humans and
related applications while CSIRO has exclusive rights for all
other applications.
“Resolution
of these patent cases provides greater clarity and confidence
for users of RNAi. CSIRO will keep providing access to the
technology through research and commercial licences,” says Dr de
Feyter.
CSIRO has
continued to develop and fine tune RNAi technology in more than
10 years of research, leading to a further nine patent families,
and establishing CSIRO as a key player in this area of research.
This was
confirmed by the recent grant of US Patent No. 6933146 to its
'Hellsgate' series of RNAi gene silencing vectors.
CSIRO is
using hairpin RNAi for a range of research purposes including
developing valuable new traits for plants and livestock
animals.
Around the
world others are using hairpin RNAi to identify the functions of
genes in plants and animals and to develop technology to combat
diseases in plants, animals and humans. |