Source: Proceedings of the National Academies of Sciences of the United States of America
http://www.pnas.org/cgi/content/abstract/0604635103v1?etoc

Overdominant quantitative trait loci for yield and fitness in tomato
Yaniv Semel, Jonathan Nissenbaum, Naama Menda, Michael Zinder, Uri Krieger, Noa Issman, Tzili Pleban, Zachary Lippman, Amit Gur, and Dani Zamir
Institute of Plant Sciences and Genetics, Faculty of Agriculture, Hebrew University of Jerusalem
Edited by Susan R. Wessler, University of Georgia, Athens, GA, and approved July 7, 2006

Heterosis, or hybrid vigor, is a major genetic force that contributes to world food production. The genetic basis of heterosis is not clear, and the importance of loci with overdominant (ODO) effects is debated. One problem has been the use of whole-genome segregating populations, where interactions often mask the effects of individual loci. To assess the contribution of ODO to heterosis in the absence of epistasis, we carried out quantitative genetic and phenotypic analyses on a population of tomato (Solanum lycopersicum) introgression lines (ILs), which carry single marker-defined chromosome segments from the distantly related wild species Solanum pennellii. The ILs revealed 841 quantitative trait loci (QTL) for 35 diverse traits measured in the field on homozygous and heterozygous plants. ILs showing greater reproductive fitness were characterized by the prevalence of ODO QTL, which were virtually absent for the nonreproductive traits. ODO can result from true ODO due to allelic interactions of a single gene or from pseudoODO that involves linked loci with dominant alleles in repulsion. The fact that we detected dominant and recessive QTL for all phenotypic categories but ODO only for the reproductive traits indicates that pseudoODO due to random linkage is unlikely to explain heterosis in the ILs. Thus, we favor the true ODO model involving a single functional Mendelian locus. We propose that the alliance of ODO QTL with higher reproductive fitness was selected for in evolution and was domesticated by man to improve yields of crop plants.

Freely available online through the PNAS open access option: http://www.pnas.org/cgi/reprint/0604635103v1