Hertfordshire, United Kingdom, and
Monheim, Germany
February 7, 2006
This venture is the first major
application of Cresset’s molecular field technology in the
agrochemical arena
Cresset BioMolecular
Discovery Ltd (Cresset BMD), a drug discovery technology
company, and Bayer
CropScience, a global market and innovation leader in the
agrochemicals industry, have announced today that they have
entered into a collaboration to exploit Cresset’s molecular
field technology for the discovery of new agrochemicals. This
venture is the first major application of Cresset’s molecular
field technology in the agrochemical arena. Bayer CropScience
will apply Cresset’s FieldScreen™ software to identify novel
early stage active compounds to progress through their
development pipeline.
Andy Vinter,
Cresset’s CSO, commented: “We are delighted to be working with
Bayer CropScience, to apply and develop our FieldScreen™
software and related technology to identify new chemotypes for
the crop science industry. Bayer CropScience has an
exceptionally experienced and innovative computational chemistry
group and we are confident that this collaboration will result
in pioneering advances in crop science research.”
Michael Schindler, Senior Scientist at Bayer CropScience,
states: "Cresset's FieldScreen technique is complementary to our
existing software tools in computational chemistry and we feel
confident that this approach provides another step towards
further improving our early phase research activities."
FieldScreen™ is based on Cresset’s revolutionary method of
modelling compounds in terms of their molecular fields rather
than their atom and bond representations which chemists are
accustomed to using. If two structurally different compounds
bind to the same region of a protein, their ‘outer skins' or
Fields must be similar despite their structural differences.
Cresset has developed technology to create and visualise
accurate fields around a molecule which can be used to model
binding interactions. The Field technology has been validated by
several major pharmaceutical companies for virtual screening
over the past year.
Cresset BioMolecular Discovery Ltd. is a drug discovery
technology company based in Letchworth, Hertfordshire, UK.
Founded in November 2001, the Company has pioneered the use of
in silico applications for the analysis of molecular fields
rather than chemical structures in drug discovery. The Company
markets its proprietary Field-based software which includes
Fieldscreen™, a virtual screening technology that rapidly
identifies diverse compounds with the same biological effects as
known actives, and FieldTemplater™ which creates bound
conformation hypotheses for active compounds to guide
hit-finding and lead optimisation projects. Cresset also
undertakes fee-for-service projects and collaborations with
shared IP. It has a global client base which includes six major
pharmaceutical companies and more than twenty biotechnology
companies.
Bayer CropScience, a subsidiary of Bayer AG with annual sales of
about EUR 6 billion, is one of the world’s leading innovative
crop science companies in the areas of crop protection,
non-agricultural pest control, seeds and plant biotechnology.
The company offers an outstanding range of products and
extensive service backup for modern, sustainable agriculture and
for non-agricultural applications. Bayer CropScience has a
global workforce of about 19,000 and is represented in more than
120 countries. |