CropDesign and Stine Seed Company in corn collaboration - TraitMill enabling technologies to be tested in corn

Gent, Belgium and Adel, Iowa
July 18, 2002

CropDesign N.V. (CropDesign) and Stine Seed Company (Stine) announced today that they have signed a corn collaboration agreement. The collaboration provides for testing certain enabling technologies from CropDesign’s TraitMill in Stine’s elite corn lines. Under the terms of the agreement, CropDesign will provide Stine with proprietary gene promoters and other enabling technologies, and Stine will carry out corn transformation, multiplication and greenhouse evaluation. CropDesign will also conduct protein and molecular characterization and will own the results of the collaboration. Stine Biotechnology receives a non-exclusive license to use the results in its own corn germplasm.

CropDesign’s TraitMill technology platform is a set of high-throughput and high resolution technologies and processes for identifying, cloning, and inserting genes into plants, as well as for phenotypical analysis of those plants and the grain/seed they produce. With the rice TraitMill, CropDesign has rapidly characterized a portfolio of proprietary promoters. These promoters have been used to express a number of traits, including increased total biomass, early vigor, seed yield, seed size and resistance to abiotic stress in rice.

According to Herman Van Mellaert, CEO CropDesign, "Developing new corn lines with improved traits for the US market requires a broad combination of skills in genomics, enabling technologies, breeding and field evaluation. This development of corn enabling technologies with Stine will strengthen both our abilities in product development, and lays a foundation for further collaboration".

Van Mellaert added, "By starting in rice we test more cereal genes more quickly and at a lower cost than in any other crop. Because of the high genetic homogeneity amongst the cereals, we get more ‘bang for our buck’ with rice than if we would be working directly in corn." Quick cycle times are important for efficient protection of intellectual property leads. With Stine we can move rice leads into corn to address the important US market".

Stine is a leading breeder and supplier of hybrid corn and soybean seed. The company was a pioneer in providing biotech traits to US farmers, and today conducts proprietary biotechnology research through its affiliate Stine Biotechnology. According to Harry Stine, President of Stine Seed Company, "Stine Seeds is excited about the potential of genomics and is committed to being

at the forefront in biotechnology. This collaboration on corn enabling technologies strengthens our ability to deliver innovative products to our dealers and farmer customers".

CropDesign, based in Gent, Belgium is an agbiotech company focused on the application of functional genomics for improved crop performance, including higher yield, heightened tolerance to stress and better quality. CropDesign applies its technology in rice, wheat and other cereals. The company technology can also be used in other business areas, including molecular farming. Founded in 1998, CropDesign employs over 75 people at its research facilities in Gent.

Stine Seed Company, located in Adel Iowa, is an industry-leading seed company focused on developing and marketing the world's best performing corn and soybean seed. Stine is the largest domestic, privately owned seed company in the U.S., Stine’s retail program is the 4th largest marketer of soybeans in the U.S., and also markets corn and soft red winter wheat. Stine Biotechnology specializes in transformation technologies, working in collaboration with the industry’s leading trait providers.

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