Paradigm Genetics announces 2002 fourth quarter and year end financial results

Research Triangle Park, North Carolina
February 20, 2003

Paradigm Genetics, Inc. (Nasdaq: PDGM), a biotechnology company, today reported financial results for the fourth quarter and year ended December 31, 2002.

"We recognize that 2002 was an extremely difficult year for Paradigm and our shareholders, as it was for the biotechnology industry as a whole," said Heinrich Gugger, Ph.D., president and CEO of Paradigm Genetics. "Despite these challenges, we have made significant tangible progress on the road to successful commercialization of our technology, which we believe will positively position Paradigm for the future. We continue to see opportunities to grow our ag biotech business, which is now contributing incremental cash flow. And we will continue to build what we believe will be a significant presence in healthcare around predictive toxicology and proprietary biomarker discovery."

Gugger continued, "The financial results for the fourth quarter include reduced revenues and incremental costs related to our previously announced steps to reposition our business to create the proper foundation for us to build on. The overall results are in line with the near-term expectations in our strategic plan and earlier earnings guidance. We remain on track with implementation of our strategic plan."

    Financial Results
    For the fourth quarter 2002, Paradigm reported:

    * A net loss from continuing operations of $6.6 million or $0.21 per share 
      compared to a net loss from continuing operations of $3.6 million or
      $0.12 per share for the same period in 2001.
    * A net loss of $9.3 million, including a loss from discontinued
      operations primarily related to the sale of its ParaGen business of $2.7
      million or $0.09 per share.
    * A decrease in total revenue of 71% to $1.9 million, compared to $6.7
      million for the same period in 2001.
    * A decrease in total operating expenses of 17% to $8.5 million, compared
      to $10.3 million for the same period in 2001.
    * An improvement in cash flow from operating activities to breakeven in
      2002 from $(6.6) million in 2001.


    For the twelve months ended December 31, 2002, Paradigm reported:


    * A net loss from continuing operations of $20.3 million or $0.63 per
      share compared to a net loss from continuing operations of $16.0 million
      or $0.59 per share for the same period in 2001.
    * A net loss of $23.5 million or $0.73 per share, including the loss from
      discontinued operations.
    * A decrease in total revenue of 30% to $17.2 million, compared to $24.5
      million for the same period in 2001.
    * A decrease in total operating expenses of 8% to $37.3 million, compared
      to $40.4 million for the same period in 2001.
    * A cash balance, comprising cash, cash equivalents and short-and long-
      term investments of $21.2 million compared to a cash balance of $43.0
      million at December 31, 2001.

Accomplishments

As discussed during the November 2002 earning conference call, Paradigm has continued its progress in the implementation of its strategic plan as follows:

    * Restructured the scope of its commercial arrangements with its ag
      partners and invested in its operations to provide the foundation for
      future profitability in its ag business.
    * Sold its ParaGen plant genotyping business to DNA Landmarks in February
      2003 for approximately $300,000 plus potential royalties. Any royalties
      will be recognized as revenues from discontinued operations in the
      Company's financial statements for the years 2003 to 2005.
    * Continued to focus on its core business activities, reduce non-essential
      recurring expenses and redirect expenditures away from SG&A toward
      healthcare R&D activities. The significant reduction in SG&A expenses
      and increasing investment in R&D will be reflected in the Company's
      financial statements in upcoming quarters.
    * Identified new business opportunities in both agriculture and healthcare
      and made significant progress on those fronts, which the company expects
      to announce in the coming months and quarters.
    * Identified key strategic partners that we believe will strengthen our
      collective offering and speed Paradigm's entry into the healthcare
      market.

Continued Gugger, "We have 'taken the medicine' we needed to take to reaccelerate the company, and now we are hitting the milestones we set for ourselves. I am fully confident in the team I have in place and am pleased with our execution on the strategy. I am greatly encouraged by our progress and look forward to sharing future successes with you."

The company will discuss earnings guidance on its February 20 conference call.

About Paradigm Genetics

Paradigm is a biotechnology company aiming to increase R&D productivity by focusing its integrated suite of technologies on the product development cycle, from target discovery to subsequent enhancement of the safety and efficacy profiles of development candidates. Paradigm chooses a systems biology approach to understand gene function in the context of biological pathways, to develop assays and biomarkers for molecular diagnostic solutions tailed to the needs of our commercial and government partners. For more information, visit www.paradigmgenetics.com.

                           PARADIGM GENETICS, INC.
                      CONDENSED STATEMENTS OF OPERATIONS
                                 (Unaudited)
                                      Three Months           Year Ended
                                          Ended
                                      December 31,           December 31,
                                    2002       2001        2002        2001
    Revenues:
    Collaborative research
     agreements                  1,632,000 $6,708,000 $16,823,000 $24,337,000
    Grant revenues                 284,000         --     360,000     130,000
    Total revenues               1,916,000  6,708,000  17,183,000  24,467,000

    Operating expenses:
     Research and
     development
     (includes $74,000 and
     $100,000 of stock based
     compensation
     expense for the three
     months ended December 31
     2002 and December 31,
     2001, respectively,
     and includes $346,000
     and $561,000 of stock
     based compensation
     expense for the
     year ended December 31
     2002 and
     December 31 2001,
     respectively)               5,674,000  7,426,000  26,386,000  28,013,000

     Selling, general and
     administrative (includes
     $46,000 and $118,000 of
     stock based
     compensation expense for
     the three months ended
     December 31, 2002 and
     December 31, 2001,
     respectively, and includes
     $317,000 and $510,000
     of stock based compensation
     expense for the year ended
     December 31, 2002
     and December 31, 2001,
     respectively)               2,851,000  2,831,000  10,909,000  12,398,000

    Total operating expenses     8,525,000 10,257,000  37,295,000  40,411,000

    Loss from operations        (6,609,000)(3,549,000)(20,112,000)(15,944,000)

    Other Interest income
     (expense), net                 31,000    (69,000)   (184,000)    (94,000)

    Net loss from continuing
     operations                 (6,578,000)(3,618,000)(20,296,000)(15,983,000)

    Discontinued operations     (2,734,000)   (65,000) (3,174,000)    (65,000)

    Net loss attributable
     to common
     stockholders              $(9,312,000)(3,683,000)(23,470,000)(16,048,000)

    Net loss per share -
     basic and
     diluted
    Loss from continuing
     operations                     $(0.21)    $(0.12)     $(0.63)     $(0.59)

    Loss from discontinued          $(0.09)        --      $(0.10)         --
     operations

    Net loss per share              $(0.29)    $(0.12)     $(0.73)     $(0.59)


    Weighted average
     common shares
     outstanding                32,019,000 30,260,000  31,974,000  27,264,000


                           Paradigm Genetics, Inc.
                            2002 Year End Results
                         Condensed Balance Sheet Data
                                 (Unaudited)
                                                 December 31,    December 31,
                                                     2002            2001
    Assets:
    Cash, cash equivalents, short-term           $10,909,000     $10,736,000
    investments
    Other current assets                           6,500,000       8,497,000
                Total Current Assets              17,409,000      19,233,000
    Long term investments                         10,323,000      32,256,000
    Property plant & equipment net                22,431,000      27,854,000
    Other non-current assets                       2,459,000       5,744,000
    Total Assets                                 $52,622,000     $85,087,000

    Liabilities and Stockholders'
    Equity:
    Current liabilities                           18,557,000      24,165,000
    Long-term obligations                          3,378,000       7,678,000
    Stockholders' equity                          30,687,000      53,244,000
    Total Liabilities and Stockholders'          $52,622,000     $85,087,000
    Equity


                            PARADIGM GENETICS, INC.
     SUPPLEMENTAL INFORMATION RE: INCREASE/(DECREASE) IN CASH, CASH

   EQUIVALENTS, SHORT-TERM AND LONG-TERM INVESTMENTS (See Note below)

                                (Unaudited)

                                       Q4           Q4          Increase/
                                      2002         2001        (Decrease)

    Cash flows from operating activities:

    Net loss attributable to
     common shareholders           (9,312,000)  (3,683,000)    (5,629,000)

    Adjustments to reconcile net
     loss to net cash used in
     operating activities           9,353,000   (2,881,000)    12,182,000

    Net cash provided by (used in)
     operating activities              41,000   (6,564,000)     6,605,000

    Net cash (used in)
      investing activities,
      excluding purchases and
      maturities
      of short-term and long-term
      investments                 (1,098,000)   (1,071,000)      (27,000)

    Net cash (used in) provided by
     financing activities         (1,171,000)   25,005,000   (26,174,000)

    Cash, cash equivalents,
     short-term
     investments and long-term
     investments beginning of
     period                       23,460,000    25,622,000    (2,162,000)

    Cash, cash equivalents,
     short-term
     investments and long-term
     investments,
     end of period                21,232,000    42,992,000   (21,759,000)

    Net (decrease) increase
     in cash,
     cash equivalents,
     short-term
     investments and long-term
     investments                 $(2,228,000)  $17,370,000  $(19,597,000)

Note: The above presentation of the change in cash and investments is not meant to be in accordance with generally accepted accounting principles ("GAAP") in the U.S. GAAP requires the presentation of a statement of cash flows only (i.e., excluding changes in short and long-term investments). Under GAAP, cash flows from investing activities above would be impacted by net sales of investment securities in the amount of $3.7 million and net purchases in the amount of $16.0 million in Q4 2002 and 2001, respectively, and, cash and cash equivalents at the beginning and end of the period would exclude short and long-term investments of $19.2 million and $15.3 million, and $21.0 million and $36.8 million for Q4 2002 and 2001, respectively. Cash, cash equivalents, short-term and long-term investments exclude restricted cash.

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