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September 27, 2005
Hierarchical metabolomics
demonstrates substantial compositional similarity between
genetically modified and conventional potato crops
Gareth S. Catchpole, Manfred Beckmann, David P. Enot, Madhav
Mondhe, Britta Zywicki, Janet Taylor, Nigel Hardy, Aileen Smith,
Ross D. King, Douglas B. Kell, Oliver Fiehn, and John Draper
PNAS published 26 September 2005, 10.1073/pnas.0503955102
http://www.pnas.org/cgi/content/abstract/0503955102v1?etoc
ABSTRACT
There is current
debate whether genetically modified (GM) plants might
contain unexpected, potentially undesirable changes in overall
metabolite composition. However, appropriate analytical
technology and acceptable metrics of compositional
similarity require development. We describe a
comprehensive comparison of total metabolites in
field-grown GM and conventional potato tubers using a
hierarchical approach initiating with rapid
metabolome "fingerprinting" to guide more detailed
profiling of metabolites where significant
differences are suspected. Central to this strategy are data
analysis procedures able to generate validated,
reproducible metrics of comparison from complex
metabolome data. We show that, apart from targeted
changes, these GM potatoes in this study appear
substantially equivalent to traditional cultivars.
http://www.pnas.org/cgi/content/abstract/0503955102v1?etoc |
